Sodium Starch Glycollate

Sodium Starch Glycolate (SSG) as per IP or USP is the sodium salt of a carboxymethyl ether of starch or of a cross-linked carboxymethyl ether of starch. It may contain a maximum of 7.0% of Sodium Chloride.

The distinguishing features of pH & assay requirements for Type A & B are as follows :

Type of SSG pH % Sodium, combined as SSG
A 5.5 to 7.5 2.8 to 4.2
B 3.0 to 5.0 2.0 to 3.4
Sodium Starch Glycollate

Super Disintegrant Action

Structure of sodium starch glycollate
Sodium Starch Glycollate

a. Crosslinked using POCl3 / Sodium Phosphate etc.
b. Non - Phosphorus Crosslinking

Sodium starch glycolate (SSG) is a super disintegrant due to its exceptional ability to promote the rapid disintegration of tablets & capsules when they encounter water or gastrointestinal fluids.

Factors that contribute to classification of SSG as a super disintegrant